A Role of Exogenous Bovine Somatotropin on Lactation and Nutrient Mobilization in Dairy Animals
Abstract
The objective of this paper was to review the role of exogenous bST effect on lactation and nutrient mobilization. Bovine somatotropin (bST) is a protein hormone that increases milk yield in dairy animals. The role of bST is to control nutrient partitioning, coordinated change in body tissues during metabolic processes, and alterations of mammary function to support increased milk synthesis. Increasing the concentrations of insulin-like growth factors IGF-I results in increasing the rates of milk synthesis per cell and improving the maintenance of secretory cells. The maximum increase in milk production has been observed up to 41%. Nutrition, the genetic makeup of the cow, physiological condition, and level of management can affect the response of bST in milk production. Circulating bST is higher in well-managed and genetically superior cows. The feed intake of cows treated with bST changed after the 8-10th week of treatment, and it had increased up to 13.4% by week 22. Also, bST-treated cows showed that the amount of mammary parenchyma and mammary epithelial cells during the first 6 weeks of lactation was not affected. The variation in milk composition due to bovine somatotropin injection was not significantly affected. In the early lactation stage, the cows mobilize their body reserves to support the increased milk production. The appropriate time preferred to start to use bST is at about peak milk yield of approximately around 60±3 day. Increase uptake of glucose, decreased oxidation of amino acids and stimulation of lipolysis are the major effect of bST during nutrient metabolism. Bovine somatotropin doesn’t have any significant adverse effect on human health; also it doesn’t affect the health and reproductive performance of the cows. Therefore, the application of bST improves dairy productivity; it makes the producers more profitable, satisfies the milk demand, and improves the livelihood of the community.
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Addisu Sh, Tegenaw K, and Tesfa A. 2018. Review on the role of bovine somatotropin hormone for dairying Online J. Anim. Feed Res., 8(4): 90-96.
Asimov, G. J. and N.K Krouze. 1937. The lactogenic preparations from the anterior pituitary and the increase of milk yield in cows. J. Dairy Sei 20:289-306
Bachman, K. C., D. H. Wilfond, H. H. Head, C. J. Wilcox and M. Singh. 1992. Milk yields and hormone concentrations of Holstein cows in response to Sometribove (Somatotropin) treatment during the dry period. J. Dairy Sci. 75:1883-1890.
Baer, R. J. Tieszen, K. 1989. Composition and flavor of milk produced by cows injected with recombinant bovine somatotropin. Journal of Dairy Science 72(6), 1424-1434.
Baldwin, R.L. and J.R. Knapp. 1993. Recombinant bovine somatotropin effects on patterns of nutrient utilization in lactating dairy cows. Am. J. Clin. Nutr. 58(Suppl. 1): 282S-286S.
Bauman, D. E., F. R. Dunshea, Y. R. Boisclair, M. A MeGuire, D. M. Hams, and KL. Housekneeht. 1989. Regulation of nutrient partitioning: homeostasis, homeorhesis, and exogenous somatotropin. Keynote Address In: F. A. Kallfelz (ed). Proceedings of the 7th International Conference on Production Disease in Farm Animals. Cornell University, Ithaca: 306-323.
Bauman, D.E. Champaign. 1992. Bovine somatotropin: review of an emerging animal technology: American Dairy Science Association; Journal of dairy science v. 75(12): 3432-3451.
Bauman, D.E. 1999. Bovine somatotropin and lactation: from basic science to commercial application. Domestic Animal Endocrinology, 17: 101-116.
Bauman, D.E. and R.G. Vernon. 1993. Effects of exogenous somatotropin on lactation. Ann. Rev. Nutr. 13:437-461.
Bauman, D.E. and W.B. Currie. 1980. Partitioning of nutrients during pregnancy and lactation: a review of mechanisms involving homeostasis and homeorhesis. J. Dairy SeL 63:1514-1529.
Bines, J.A., Hart, I.C., 1982. Metabolic limits to milk production, especially roles of growth hormone and insulin. J. Dairy Sci. 65: 1375-1389.
Butler, A. A. and D. L. Le Roith. 2001. Control of growth by the somatotropic axis: Growth hormone and the insulin-like growth factors have related and independent roles. Annu. Rev. Physiol. 63:141-164.
Chaiyabutr N, S. Komolvanich, S. Thammacharoen and S. Chanpongsang. 2003. The Plasma Level of Insulin-like Growth Factor-I (IGF-I) in R이ation to Mammary Circulation and Milk Yield in Two Different Types of Crossbred Holstein Cattle. Thailand.
Clemmons, D.R., and LE. Underwood. 1991. Nutritional regulation of IGF-1 and IGF binding proteins. Annu. Rev. Nutr. 11:393-412.
Davis SR, Collier RJ, McNamara JP, Head HH, and Sussman W. 1988a. Effects of thyroxin and growth hormone treatment of dairy cows on milk yield, cardiac output and mammary blood flow. J. Anim. Sci. 66: 70.
Davis, S. R., S. C. Hodgkinson, P. D. Gluckman, L. G. Moore, and B. H. Breier. 1988b. The mechanism of action of growth hormone on milk production in ruminants. Proc. N. Z. Soc. Anim. Prod. 48: 191
Davis, S.R., Collier, R.J. 1985. Mammary blood flow and regulation of substrate supply for milk synthesis. J. Dairy Sci., 68: 1041-1058
Dohoo, I.R., DesCôteaux, L., Leslie, K., Fredeen, A., Shewfelt, W., Preston, A. and Dowling, P. 2003. A meta-analysis review of the effects of recombinant bovine somatotropin: 2. Effects on animal health, reproductive performance, and culling. Canadian Journal of Veterinary Research, 67: 252.
Eisenbeisz, Wade. 1988. "Lactational Evaluation of Recombinant Bovine Somatotropin with Corn and Barley Diets". Electronic Theses and Dissertations. 1329.
Elivinger, F., J.H. Head, C.J. Wilcox, R.P. Natzke and R.G. Eggert. 1988. Effect of Administration of Bovine Somatotropin on Milk Yield and Composition. J. Dairy Sci. 71: 15:15
Eppard, P.1, D. E. Bauman, I Bitman, D. L. Wood, R. M. Akers, and W. A. House. 1985. Effect of dose of bovine growth hormone on milk composition: a lactalbumin, fatty acids and mineral elements. J Dairy Sci. 68:3047.
Eppard, P.1, G.M. Lasa, S. Hudson, W. I Cole, IL L. Hartz, T. C. White, W. E. Ribelin, B. G. Hammond, S.C. Bussen, R. K. Leak, and L. E. Metager. 1992. Response of lactating dairy cows to multiple injections of sometribove, USAN (recombinant methionyl somatotropin) in a prolonged release system. Part 1. Production response. J. Dairy Sci. 71(1): 184.
Etherton, T.D., Bauman, D. E., 1998: The biology of somatotropin on growth and lactation of domestic animals. Physiol. Rev. 78: 745-761.
Folley, S. J., and F. G. Young. 1943. The galactopoietic action ·of pituitary extracts in lactating cows. I. Dose-response relations and total yields during declining lactation. J. Endocrinology, 4,194.
Fullerton, F. M., Fleet, I. R. Heap, R.B., Hart, I. C., Mepham, T.B. 1989. Cardiovascular responses and mammary su BST rate uptake in Jersey cows treated with pituitary-derived growth hormone during late lactation. Journal of Dairy Research 56(1): 27-35.
Gertler, A., A. Ashkenazi and Z. Madar. 1984. Binding sites of Human Growth Hormone and Ovine and Bovine Proloctins in the Mammary Gkland and in Liver of Lactation Dairy Cows Mol. Cell Endocr. 34:51.
Glim, D. R., V. E. Baracos, and J. T. Kennelly. 1988. Effect of bovine somatotropin on the distribution of immunoreactive insulin-like growth factor-I in lactating bovine mammary tissue. J. Dairy Sci. 71:2923.
Gluckman, P. D., B. H. Breier, and S. R. Davis. 1987. Physiology of the somatotropic axis with particular reference to the ruminant. J. Dairy Sci. 7 0: 442.
Gulay, M., Hayen, M., Teixeira, L., Wilcox, C. and Head, H. 2003. Responses of Holstein cows to a low dose of somatotropin (bST) prepartum and postpartum. Journal of Dairy Science, 86: 3195-3205.
Haben Fesseha, Saliman Aliye and Temesgen Kifle. 2019. A Review on Recombinant Bovine Somatotropin and its Role in Dairy Production: Theriogenology Insight: 9(3): 77-86.
Jabbar MA. 2009. Long term use of bovine somatotropic (bST) on reproduction and health of Nili -Ravi buffaloes, 39(1): 266–269.
Knight, C.H., Brown, J.R., Sejrsen, K.A. 1994: A comparison of growth hormone induced mammo genesis in pregnant and lactating goats. Endocrinol. Metab.; 1(suppl B): 52.
Lynch, J.M.; Barbano, D.M., Bauman, D.E., Hartnell, G.F., Nemeth, M.A. Champaign, Ill. 1992. Effect of a prolongerelease formulation of N-methionyl bovine somatotropin on milk fat. American Dairy Science Association.
McDowell, G. H., D. Leenanuruksa, P. Niumsup, J. M. Gooden, J. G. van der Walt, and R. Smithard. 1988. Short term effects of exogenous growth hormone: effects on milk production and utilization of nutrients in muscle and mammary tissues of lactating ewes. J. Biol. Sci. 41:279.
McDowell, G. H., J. M. Gooden, D. Leenanuruksa, M. Jois and A. W. English. 1987. Effects of exogenous growth hormone on milk production and nutrient uptake by muscle and mammary tissues of dairy cows in mid lactation. J. Biol. Sci. 40: 295.
McGuffey, R.K., H.B. Green, R.P, Basson and T.H. Ferguson. 1990. Lactation response of Dairy Cows Receiving Bovine Somatotropin via Daily injections or in a Sustained release vehicle J. Dairy Sci. 73:763.
Mehmet fiükrü GÜLAY, Fatma fiefika. 2005. Use of Bovine Somatotropin in the Management of Transition Dairy Cows, Turk J Vet Animal Science 29: 571-580.
Mepham, T. B., S. E. Lawrence, A. R. Peters, and I C. Hart. 1984. Effects of exogenous growth hormone on mammary function in lactating goats. Horm. Metab. Res. 16:248.
National Research Council (NRC). 1994. Metabolic Modifier-Effect on the Nutrient Requirement of Food Producing Animals. National Academy Press, Washington, DC.
Peel, C.J., L.D. Sandles, K.J.Queolch and A.C. Herington. 1985. The effect of Long term Administration of Bovine Growth.
Phipps, R. H., Madakadze, C. Mutsvangwa, T., Hard, D.L., de Kerchove G., 1991. Use of bovine somatotropin in the tropics: the effect of some tribove on milk production of Bos indicus, dairy crossbred and Bos taurus cows in Zimbabwe. Journal of Agricultural Science, Cambridge 117: 257-263.
Politis, L., E. Block and J.D. Turner, 1990. Effect of Somatotropin on the Plasminogen and Plasmin System in the Mammary Gland: Proposed Mechanism of Action for Somatotropin on the Mammary gland. J. Dairy Sci. 73: 1494.
Prosser, C. G. and Mepham, T. B., 1989. Mechanism of action of bovine somatotropin in increasing milk secretion in dairy ruminants. In Use of Somatotropin in Livestock Production,
Prosser, C.G., Davis, S.R., Farr, I., Lacasse, P. 1996. Regulation of blood flow in the mammary microvasculature. J. Dairy Sci., 79: 1184-1197.
Raux, Axel. Bichon, Emmanuell. Benedetto, Alessandro. Pezzolato, Marzia. Bozzetta, Elena. Le Bizec, Bruno. Dervilly, Gaud. 2022. The Promise and Challenges of Determining Recombinant Bovine Growth Hormone in Milk. J. Food. 11(3): 1-13
Raymond, Richard, Bales, Connie W, Bauman, Dale E, Clemmons, David, Kleinman, Ronald, Lanna, Dante, Nickerson, Stephen, Sejrsen, Kristen. 2009. Recombinant Bovine Somatotropin (rbST): A Safety Assessment Initially. Annual Meeting of American Dairy Science Assoc, Canadian Society of Animal Science and American Society of Animal Science
Richard, A. L., s. N. McCutcheon, and D. E. Bauman. 1985. Responses of dairy cows to exogenous bovine growth hormone administered during early lactation. J. Dairy Sci. 68:2385.
Rock, D. W., D. L. Patterson, W. V. Chalupa, J. H.Clark, R. M. DeGregorio, and B. F. Jenny. 1989. Lactation performance of dairy cows given a sustained release form of recombinant bovine somatotropin. J. Dairy Sci. 72(Suppl. 1):431.
Ronge, H., J. Blum, C. Clement, F. Jans, H. Leuenberger and H. Binder. 1988. Somatomedin C in dairy cows related to energy and protein supply and to milk production. Anim. Prod. 47:165-183.
Sarwar M and Tanveer A. 2002. Effect of Bovine Somatotropin on the Lactational and Reproductive Performance of Lactating Dairy Cows, A Review, Journal Science Vision 8(1).
Scientific Committee on Animal Health and Animal Welfare (SCAHAW). 1999. Report on Animal Welfare Aspects of the Use of Bovine Somatotropin.
Shibru, D. 2016. Review on the effect of using recombinant bovine somatotropin (rbST) hormone on dairy cattle production. Glob. J. Inc., 18-30.
Soderhalm, C. G., D. E. Otterby, J. G. Linn, F. R. Ehle, J.E. Wheaton, W. P. Hansen, and R. J. Annexstad. 1988. Effects of recombinant bovine somatotropin on milk production, body composition, and physiological parameters. J. Dairy Sci. 71:355.
Soliman EB. 2014. Physiological responses of dairy animals to recombinant bovine somatotropin: 1–14.
Tadesse Mihret, Fentahun Mitku and Tadesse Guadu. 2017. Dairy Farming and its Economic Importance in Ethiopia: A Review, World Journal of Dairy & Food Sciences 12(1): 42-51.
Tanwattana P, S. Chanpongsang and N. Chaiyabutr. 2002. Effects of Exogenous Bovine Somatotropin on Mammary Function of Late Lactating Crossbred Holstein Cows. Department of Animal Husbandry, Faculty of Veterinary Science, Thailand.
Vernon, R. G., M. Barber, E. Finley, and M. R. Grigor. 1988. Endocrine control of lipogenic enzyme activity in adipose tissue from lactating ewes. Proc. Nutr. Soc. 47:100
Walstra, P. and R. Jenness. 1984. Dairy chemistry and physics. Wiley, New York, NY: 24
Whitaker, D. A., E. J. Smith, J. M. Kelly, and L. S. Hodgson-Jones. 1988 . Health, welfare and fertility implications of the use of bovine somatotropin in dairy cattle. Vet. Rec. 122: 503.
Young, F.G., 1947. Experimental stimulation of lactation. Br. Med. Bull; 5: 155-160.
Zhao, X, J.H. Burton, B.W. Mc Bride. 1992. Lactation, health and reproduction of dairy cows receiving daily injectalile or sustained release somatotropin. J. Dairy SCI. 75(11):3122-30. doi: 10.3168/jds.S0022-0302(92)78075-8.
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